Disturbances in Fibronectin after Trauma: Relationship to Altered Reticuloendothelial Function Mechanisms,
ALBANY MEDICAL COLL NY
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Traumatic injury and its sequelae, which many times consist of infection or sepsis and multiple organ dysfunction, are a major medical problem in civilian practice and military medicine. Although the literature concerning the physiopathology of trauma is voluminous, our current understanding is very poor concerning what causes some patients to develop post-traumatic morbidity and mortality while other patients seem to tolerate a similar degree of injury without significant post-traumatic complications. One important aspect of the post-traumatic resistance includes a the ability of host defense processes to protect the organism from endogenously generated toxic substances and b the protection of the organism from exogenous bacterial infection and other toxic substances. The research carried out in our laboratory over the last dozen years has investigated the participation of the reticuloendothelial system in host defense processes that are involved in pathophysiological reactions to traumatic injury and shock.