Prevention of Ischemia-Induced Acute Renal Failure,
COLORADO UNIV AT DENVER DEPT OF MEDICINE
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Mannitol, furosemide, prostaglandin E2, and verapamil have been demonstrated to be protective against ischemic acute renal failure. Although the functional improvements in such renal parameters as glomerular filtration rate and tubular reabsorption of sodium are clearly demonstrable after therapy, the cellular mechanisms that underlie the decreased renal function are not well understood. These pharmacological agents exert multiple physiological effects, and it has been difficult to attribute their protective effects to a common mechanism. However, new insights into the protective role of each of these drugs have been derived from our sequential studies of mitochondrial function during and following ischemia in both the intrarenal norepinephrine model NE 0.75 mgkgmin and the renal artery clamp model 45-50 min of ischemic acute renal failure ARF in dog and rat, respectively.