Results of Animal Experiments as a Basis for Recommendations on Therapy of Combined Injuries (Radiation Injury Plus Wounds),
LABORATORIUM FUER EXPERIMENTELLE RADIOLOGIE NEUHERBERG/MUNICH (GERMANY F R)
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The treatment of combined injuries must always be seen against the background of the radiation syndrome therapy. All combined injuries have a set of symptoms in common general treatment principles can be adjusted to these symptoms. Almost all additional injuries worsen the development and prognosis of the radiation disease. Radiation doses whose effects are far below the limit of lethality can become life endangering in the presence of serious injuries or burns. The susceptibility for shock is extremely increased. Not much is known yet about the combination injury shock in people one can assume, however, that its treatment should be similar to that of a wound shock without additional exposure to irradiation. Warmth, quiet, control of pain, and stabilization of the circulatory system should be mentioned here. The healing of wounds, burns, and open fractures in the initial phase of the radiation disease does not always differ from the healing in non-irradiated patients however, when the agranulocytosis starts, very serious wound infections can occur, which can even lead to necrosis. The method of choice is a primary wound suturing as soon as possible after the combined injury. Local and general antibiotic therapy should not be omitted.