Accession Number:

ADD018948

Title:

Surface Modification of Polymers with Self-Assembled Monolayers that Promote Adhesion, Outgrowth and Differentiation of Biological Cells

Descriptive Note:

Patent, Filed 28 Apr 94, patented 24 Feb 98

Corporate Author:

DEPARTMENT OF THE NAVY WASHINGTON DC

Report Date:

1998-02-24

Pagination or Media Count:

24.0

Abstract:

A process for forming spatially oriented neo-vascular capillaries comprising a providing a combination ultra-thin film UTF pattern of at least one cell adhesion promoter and at least one cell adhesion inhibitor wherein the cell adhesion promoters nave a linewidth of between about 50-490 microns b seeding the combination UTF pattern with endothelial cells at an initial seeding cell density c adding a first medium for incubating the seeded endothelial cells until the endothelial cells are grown to confluency d replacing the first medium with a second medium at confluency and e allowing the endothelial cells to differentiate into spatially oriented neo-vascular capillaries.

Subject Categories:

  • Anatomy and Physiology
  • Adhesives, Seals and Binders

Distribution Statement:

APPROVED FOR PUBLIC RELEASE