Accession Number:

ADD018363

Title:

Antisense Oligonucleotides Directd against Human ICAM-I RNA.

Descriptive Note:

Patent, Filed 12 Oct 93, patented 3 Dec 96,

Corporate Author:

DEPARTMENT OF THE NAVY WASHINGTON DC

Report Date:

1996-12-03

Pagination or Media Count:

16.0

Abstract:

The present invention provides a method for the treatment of septic shock and inflammatory complications of shock. A process for selectively inhibiting the expression of the human ICAM-I mRNA transcript using at least one oligonucleotide which is complementary to at least a portion of the human ICAM-I mRNA is disclosed, as are oligonucleotides which are complementary to portions of the ICAM-I mRNA and compositions comprising the oligonucleotides.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE