Accession Number:

ADD018075

Title:

Process for the Preparation of Headgroup-Modified Phospholipids Using Phosphatidylhydroxyalkanols as Intermediates.

Descriptive Note:

Patent, Filed 11 May 95, patented 14 May 96,

Corporate Author:

DEPARTMENT OF THE NAVY WASHINGTON DC

Personal Author(s):

Report Date:

1996-05-11

Pagination or Media Count:

8.0

Abstract:

Phospholipase D enzyme is used to mediate the synthesis of a phosphatidylhydroxyalkanol in a first step. This phosphatidyihydroxyalkanol is reacted to produce a headgroup modified phospholipid in a subsequent step. In the first step, phospholipase D enzyme extract mediates transphosphatidylation of a phospholipid with an alcohol containing at least two hydroxyl groups per molecule producing reproducible and nearly quantitative yields of a phosphatidylhydroxyalkanol. In the subsequent step, the hydroxyl head group of the phosphatidylhydroxyalkanol is further reacted with amino carboxylic, halogen or thiol containing molecules to produce a headgroup modified phospholipid.

Subject Categories:

  • Inorganic Chemistry
  • Organic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE