Recombinant Leishmania Containing Genes Encoding Proteins From Infectious Disease Agents and Method of Inducting Cellular Immune Response.
Patent Application, filed 5 Apr 93,
DEPARTMENT OF THE NAVY WASHINGTON DC
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This invention relates to recombinant strains of Leishmania which express foreign proteins, useful for vaccination against infectious diseases. More particularly, this invention relates to strains of Leishmania expressing the circumsporozoite protein, sporozoite surface protein 2, or other Plasmodium antigens which, when administered as vaccine components, either alone or in combination with other malarial antigens, can confer protective immunity against malaria
- Medicine and Medical Research