Protective Malaria Sporozoite Surface Protein Immunogen and Gene.
Patent, Filed 10 Jan 91, patented 30 Mar 93,
DEPARTMENT OF THE NAVY WASHINGTON DC
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A protein antigen SSP2 on the surface of Plasmodium sporozoites is disclosed as a candidate immunogen for vaccination against malaria. This use of this protein, which is distinct from the extensively characterized circumsporozoite CS protein, will also facilitate research into host immunological responses to malaria. This antigen is detected by a monoclonal antibody NYS4 which is specific for a 140 kilodalton kD protein on the sporozoite cell surface. Immunoreactive genomic clones are described which express this surface antigen gene and the primary nucleic acid sequence and the deduced amino acid sequence derived from this DNA sequence are disclosed. Unique repetitive sequences of amino acids are described which further demonstrate the distinction between SSP2 and the CS protein.
- Medicine and Medical Research