Accession Number:

ADD015650

Title:

Radioactively Labelled Macromolecules.

Descriptive Note:

Patent Application, Filed 2 Apr 92,

Corporate Author:

DEPARTMENT OF THE NAVY WASHINGTON DC

Personal Author(s):

Report Date:

1992-04-02

Pagination or Media Count:

11.0

Abstract:

A method for making a radioactively labeled macromolecular substance includes the steps of reacting a first bidentate ligand including at least two heterocyclic nitrogens with a macromolecule to form a modified macromolecule reacting a radioactive metal ions having one member of the group selected from 97 Ru , 52 Fe, 191 Os and 67CU ions, with a second bidentate ligand including at least two heterocyclic nitrogens and a third bidentate ligand including at least two heterocyclic nitrogens, to form a metal-bidentate ligand complex, the first second and third bidentate ligand being the same or different and reacting the metal-bidentate ligand complex with the modified macromolecule to form a radioactively labeled substance. The radioactively labeled macromolecular substances may be used for a variety of purposes such as a tumor localization reagents for positron emission tomography and other scintilligraphy methods.

Subject Categories:

  • Physical Chemistry
  • Geodesy
  • Atomic and Molecular Physics and Spectroscopy

Distribution Statement:

APPROVED FOR PUBLIC RELEASE