Radioactively Labelled Macromolecules.
Patent Application, Filed 2 Apr 92,
DEPARTMENT OF THE NAVY WASHINGTON DC
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A method for making a radioactively labeled macromolecular substance includes the steps of reacting a first bidentate ligand including at least two heterocyclic nitrogens with a macromolecule to form a modified macromolecule reacting a radioactive metal ions having one member of the group selected from 97 Ru , 52 Fe, 191 Os and 67CU ions, with a second bidentate ligand including at least two heterocyclic nitrogens and a third bidentate ligand including at least two heterocyclic nitrogens, to form a metal-bidentate ligand complex, the first second and third bidentate ligand being the same or different and reacting the metal-bidentate ligand complex with the modified macromolecule to form a radioactively labeled substance. The radioactively labeled macromolecular substances may be used for a variety of purposes such as a tumor localization reagents for positron emission tomography and other scintilligraphy methods.
- Physical Chemistry
- Atomic and Molecular Physics and Spectroscopy