Protective Four Amino Acid Epitope Against Plasmodium vivax Malaria.
Patent, Filed 6 Nov 90, patented 10 Mar 92,
DEPARTMENT OF THE NAVY WASHINGTON DC
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A synthetic peptide of the human malaria Plasmodium vivax, containing at least one repeat of a synthetic peptide having the amino acid sequence Ala-Gly-Asp-Arg AGDR which is a protective epitope found on the circumsporozoite CS protein of the sporozoites of the human malaria Plasmodium vivax. When a monoclonal antibody specific for this four amino acid sequence binds to the CS protein of the P. vivax sporozoite in vivo, infection is prevented. Also described are pharmaceutical formulations of these peptides.
- Medicine and Medical Research