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Blood Substitute Comprising Liposome-Encapsulated Hemoglobin.
Patent, Filed 9 May 88, patented 27 Mar 90,
DEPARTMENT OF THE NAVY WASHINGTON DC
Pagination or Media Count:
It is an object of the present invention to provide a blood substitute or blood extender, for administration to human or animal patients. It is another object of the present invention to provide such a substitute which is also an oxygen carrier, based upon hemoglobin. It is a further object of the present invention to provide a blood substitute or extender capable of circulating many hours within the circulatory system of the recipient and having adequate oxygenation characteristics. It is still another object of the present invention to provide a blood substitute or extender consisting of hemoglobin-containing liposomal vesicles which are of nearly a uniform size, averaging 0.2 microns in diameter, having generally a simple lipid bilayer and which are sterilizable. It is yet another object of the present invention to provide a process for preparing a blood substitute or blood extender without chemical reaction to modify native hemoglobin.
APPROVED FOR PUBLIC RELEASE