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Method for the Production of Lipid Based Tubules by Double Thermal Cycle.
Patent Application, Filed 16 Sep 88,
DEPARTMENT OF THE NAVY WASHINGTON DC
Pagination or Media Count:
This invention relates to an efficient method for the production of lipid based tubules by a double thermal cycle. In recent years there has been an increasing interest in the use of synthetic lipid structures for a variety of applications including model membranes, immunological adjuvants, drug carriers, artificial blood substitutes and the like. The preparation of liposomes provide a practical and effective means for encapsulating liquids and solids. Liposomes are particularly useful for administrating biologically active substances into living organisms. The liposome protects substances from destruction or inactivation by bodily processes or by organisms until the substance reaches the desired reaction site in the body. Tubules are formed rapidly and in quantity by hydrating a diacetylenic lipid at a temperature about 10 C above its endothermic transition temperature, dispersing the lipid to form a suspension of small unilamellar vesicles, lowering the temperature of the suspension to 0 C at a rate of less than 1.5 C per minute, subsequently raising the temperature of the suspension to about 10 C above the endothermic transition temperature of the lipid at a rate of less than 1.5 C per minute, and lowering the temperature of the suspension to ambient room temperature at a rate of less than 1.5 C per minute to form tubules. Patent applications. AW
APPROVED FOR PUBLIC RELEASE