Technique for Drug and Chemical Delivery.
Patent Application, Filed 5 Aug 86,
DEPARTMENT OF THE AIR FORCE WASHINGTON DC
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This invention relates generally to a technique for delivering drugs andor chemicals, and, more particularly, to effecting such delivery by means of microwave-stimulation of drug containing liposomes. By subjecting liposome encapsulated drugs to microwave radiation the normal phase transition temperature of the lipsome is reduced. The microwave radiation may range between 26-2450 MHz in order to effect the release of drugs andor chemicals from the lipsomes. In a buffered saline, for example, microwave exposure triggers the onset of drug release at 33 C whereas in plasma a near maximal release is observed as low as 27 C. Drug release is enhanced by oxygen and is attenuated by antioxidants. It is clearly established, therefore, by the technique of the present invention that the permeability of liposomes are greatly influenced by nonionizing electromagnetic radiation. This interaction can be modulated by two physiologically important factors, plasma and oxygen. Consequently, the technique of the present invention is an extremely effective medical tool to rapidly deliver drugs andor chemicals into localized areas of the human body in order to effect the treatment of disease.