Gas Driven System for Preparing Large Volumes of Non-Oxidized, Pyridoxylated, Polymerized Stroma-Free Hemoglobin Solution for Use as a Blood Substitute.
Patent, Filed 10 Oct 86, patented 15 Mar 88,
DEPARTMENT OF THE AIR FORCE WASHINGTON DC
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The present invention relates generally to apparatus and methods for mixing chemicals, and more specifically to apparatus and methods that minimize production of unwanted byproducts when mixing dilute concentrations of chemicals. An apparatus and method for reacting dilute concentrations of delicate bioorganics or other reactants without creating microconcentrations of reactant during the reaction process. The apparatus mixes reagents inside of Y-connector with flowing solution from a solution reservoir. The reagents are introduced through a stopcock controlled infusion port at the center of the Y-connector. Solution and pressurized gas are each supplied to one of the three legs of the Y-connector and the resulting mixed solution from the third leg of the Y-connector is lifted by bubbles of the pressurized gas to return to the solution reservoir. A gaseous separation unit is placed inside the solution reservoir wherein the bubble lifted and mixed solution is forced through a permeable membrane enclosed by a perforated bulb to return to the reservoir. The perforated bulb is enclosed inside an additional enclosure having an opening below the solution level of the reservoir so that the returning sulution will flow beneath the opening to the larger reservoir area and the excess gas will escape above the solution level through vent holes in the additional enclosure. Additional pressurized gas is delivered to the enclosure opening to bubble over the outside of the perforated bulb. A second Y-connector may be added between the first Y-connector and the solution reservoir.