Process for the Preparation of Detoxified Polysaccharide-Outer Membrane Protein Complexes, and Their Use as Antibacterial Vaccines.
Patent, Filed 17 Sep 85, patented 17 Nov 87,
DEPARTMENT OF THE ARMY WASHINGTON DC
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This invention relates to a novel means for affording treatment and control of infections in animals, including human beings and other mammalian species, which may becaused by gram-negative bacteria. It is based upon the use or administration of immunogenically effective amounts of a detoxified polysaccharide-outer membrane protein complex against infection by the same bacteria from which it has been derived. The term polysaccharide as used herein includes lipopolysaccharides and capsular polysaccharides.