Conversion of Prostaglandin Analogs into a Bicarbonate Insoluble Oligomeric Mixture.
Patent, Filed 6 May 83, patented 5 May 87,
DEPARTMENT OF THE NAVY WASHINGTON DC
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A method for oligomerization of a group of prostaglandin analogs such as the Ethyl Analog 3-trans-3-keto-1-pentenyl1-2ethyl-2-cyclopentenone into a biologically active exhibiting protection of oxidative phosphorylation of degenerated mitochondria and sodium bicarbonate insoluble oligomeric mixtures is described. The Ethyl Analog is treated with ethanolic potassium hydroxide solution in an oxygen-free atmosphere at moderate conditions of temperature, time and concentration.
- Polymer Chemistry