Accession Number:

ADD012000

Title:

5-(Straight Chain 3-12 Carbon Alkoxy)-8-Quinolinamines and Their Use for Treatment of Malaria.

Descriptive Note:

Patent,

Corporate Author:

DEPARTMENT OF THE AIR FORCE WASHINGTON DC

Personal Author(s):

• Saggiomo,Andrew J.
• Nodiff,Edward A.

Report Date:

1985-11-19

Pagination or Media Count:

14.0

Abstract:

The present invention relates to novel improvements in the chemotherapy of malaria, consisting in the development of new primaquine analogues which exhibit practical levels of effectiveness in experimental malaria both when induced by sporozoites of infectious Plasmodia and by introduction of infectious trophozoites of the parasites. Such range of chemotherapeutic effectiveness against forms of the malaria parasite both in tissues and in blood affords a unique melding of worth especially because achieved without the gross liability of hazardous toxic side-effects otherwise characteristic of 8-aminoquinolines. In truth, such new primaquine analogues provide a remarkably broad spectrum of antimalarial activity in relation to the life cycle of the parasite. Practical utility of the class as being both clinically curative and radically curative antimalarials is envisioned.

Descriptors:

• *PATENTS
• *ANTIMALARIALS
• *PRIMAQUINE
• *CHEMOTHERAPY
• *MALARIA
• ANALOGS
• QUINOLINES
• AMINES
• ALKOXY RADICALS
• SYNTHESIS(CHEMISTRY)

Subject Categories:

• Medicine and Medical Research
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE