Method for Introducing Fluorine into an Aromatic Ring.
DEPARTMENT OF THE AIR FORCE WASHINGTON DC
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The present invention concerns itself with a method for introducing fluorine into an aromatic ring structure by using NF4BF4 as a reaction reagent. The introduction is accomplished by an electrophilic substitution reaction in which up to five hydrogen atoms in the aromatic ring can be substituted by fluorine atoms. The reaction can be carried out by either adding the aromatic compound, such as benzene in vapor form, to a cooled solution of NF4BF4 in HF or, alternatively, by adding slowly a solution of NF4BF4 to a solution of benzene in HF.
- Organic Chemistry