Treatment of Malaria with Liposomes Containing 8-Aminoquinoline Derivatives and Glycoconjugates.
DEPARTMENT OF THE ARMY WASHINGTON DC
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A novel treatment has been discovered for interrupting the life cycle of the malaria parasite during its development in the liver of the vertebrate host. The subject invention involves a method of chemotherapy against sporozoite-induced malaria by administering an 8-aminoquinoline drug, such as primaquine, encapsulated within liposomes containing glycoconjugates, to a vertebrate host which has been infected with sporozoites of the parasites. Preferred species of glycoconjugates have a terminal glucose or galactose moiety, such as present in glycosyl ceramide, galactosyl ceramide, lactosyl ceramide, or in glycoproteins. Author