Accession Number:

ADB957358

Title:

Phosgene: Median Lethal Concentrations for Mice: 2- and 30-Minute Exposures

Descriptive Note:

Corporate Author:

EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD

Report Date:

1941-11-22

Pagination or Media Count:

19.0

Abstract:

The object of project A 10.2 is to determine the toxicity of various substances in order to estimate their value as possible war agents. The object of the work described in this report was to determine the median lethal concentrations of phosgene for white mice for exposure periods of 2 and 30 minutes and an observation period of ten days. The work was done in order to secure additional data for comparison of the toxicity of cyanogen chloride, hydrocyanic acid and phosgene. Conclusions 1. The median lethal concentration of phosgene for white mice, for an exposure period of 2 minutes and an observation period of ten days, is 2.35 mgl, with an average deviation of 0.25 mgl. 2. The median lethal concentration of phosgene for mice, for an exposure period of 30 minutes and an observation period of ten days, is 0.112 mgl, with an average deviation of 0.016 mgl.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE