Accession Number:

ADB956567

Title:

Toxicity of Phosgene to White Mice by Inhalation

Descriptive Note:

Corporate Author:

EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD

Personal Author(s):

Report Date:

1932-11-21

Pagination or Media Count:

23.0

Abstract:

Object The object of this work was to provide accurate and adequate data on the toxicity of phosgene by inhalation on white mice for a 10-min. exposure. Discussion In the case of a gas like phosgene, where the chief cause of death is pulmonary edema, it is possible that deaths occurring within 48 hours after exposure are the best index of the toxicity of the gas. However, in order to provide all figures that may be required for comparison with other gases 5 day and 10 day mortalities are also given. Conclusions The experimental lethal concentration for phosgene for a 10 minute exposure, and an observation period of 2 days 48 hours, can be placed at 0.375 to 0.377 mgl. The experimental lethal concentration for phosgene for a 10 minute exposure, and an observational period of 5 days, is slightly greater than 0.366 mgl. The median lethal concentration for phosgene, as read from the curve, for a 10 minute exposure 48 hour observation, is 0.375 mgl.

Subject Categories:

  • Toxicology
  • Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE