Accession Number:

ADB370363

Title:

Chemical Warfare Agent Operational Exposure Hazard Assessment Research: FY07 Report and Analysis

Descriptive Note:

Final rept. Oct 2006-Sep 2007

Corporate Author:

ARMY EDGEWOOD CHEMICAL BIOLOGICAL CENTER APG MD RESEARCH AND TECHNOLOGY DIR

Report Date:

2010-07-01

Pagination or Media Count:

152.0

Abstract:

Contact hazard, defined as the toxicological hazard arising from any potentially contaminated surface that is capable of transferring toxic quantities of chemical agent to the skin, is studied in a series of animal models. Physiological parameters were developed in the guinea pig model to compare toxicity and kinetic data for the nerve agents, VX, GB, or GF, and to determine lethal percutaneous PC levels of VX. Calibration of Physiologically-based pharmacokinetic biomarkers dose-metrics were determined in a miniature swine model, achieving very sensitive detection levels for GBGF products in plasma and tissue partition coefficients for VX. Rabbit studies extended the dose-response data for PC exposure to VX. The comparison of neat and dilute VX doses indicates that for a PC exposure, the VXIPA VX in isopropyl alcohol solution was two times more potent than the neat agent for the ED50mild and ED50moderate.

Subject Categories:

  • Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE