Frequency-Domain Optical Mammogram
Final rept. 1 Oct 1999-30 Sep 2002
TUFTS UNIV MEDFORD MA
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This research project has involved the analysis of a clinical data set of frequency-domain optical mammograms -150 patients to maximize the effectiveness of this breast imaging modality for cancer detection and to guide further improvements of this technique. During the first year, we have computed edge-corrected optical mammograms N-images for the whole data set and obtained the corresponding ROC curve. During the second year, we have devised a new approach to tumor oximetry on the basis of spectral data, and we have started developing a second-derivative scheme of image processing. During the third year, we have finalized the second-derivative processing scheme and applied it to the whole set of clinical data. By combining the information provided by the second- derivative optical mammograms at one wavelength, and the oxygenation images computed from data at four wavelengths, we have obtained a new ROC curve that shows a significant improvement upon the ROC curve based on the N-images alone. In summary, we have completed our broad objectives 1 maximize the clinically useful information extracted from the existing set of optical mammograms 2 guide further developments of optical mammography by introducing a new approach to tumor oximetry.
- Medicine and Medical Research