Mapping Genetic Modifiers of Mammary Tumor Susceptibility in BALB/c-Trp53+/-Mice
Final rept. 1 Sep 2000-31 Aug 2002
MASSACHUSETTS UNIV AMHERST
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The TP53 tumor suppressor gene is defective in the majority of sporadic breast cancers. Breast cancer is also the most frequent tumor type in women with Li-Fraumeni syndrome who inherit germline mutations in TP53. This suggests that p53 is fundamental to the growth regulation and prevention of tumors in the mammary epithelium. However, the incidence of mammary tumors in p53-deficient mice varies greatly among strains. We have undertaken the genetic mapping of modifiers of susceptibility by performing genetic crosses between mammary tumor-susceptible BALBc-Trp53- mice and -resistant C57BL6-Trp53- mice. Mammary tumor susceptibility was shown to segregate as a partially dominant trait with recessive-acting modifiers also detected.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research