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Insulin and Breast Cancer Risk
Final rept. 1 Jun 1999-31 May 2002
STATE UNIV OF NEW YORK AT BUFFALO AMHERST
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There is biological evidence that glucose and other factors related to glucose metabolism, such as insulin and insulin-like growth-factors IGFs may contribute to breast cancer development. Glucose,may play a direct role in the development of breast cancer by favoring the selection of malignant cell clones 1. Neoplastic cells have been shown to extensively utilize glucose for proliferation I. Increased metabolism of glucose toward the pentose phosphate pathways is one of the central metabolic characteristics of malignant tissues 2. In addition, insulin is a powerful mitogenic agent. In cell culture, insulin induce-s dose-dependent growth response in breast cancer cell lines acting via insulin receptor 3-5. Moreover, insulin may also play a role in tumor promotion by upregulation of ovarian steroid secretion 6,7. Intraportal insulin levels influence IGF-l bioavailability 8. IGF-I is a small peptide about 7,500 DA with significant structural homology with proinsulin and insulin 9, and is highly regulated by growth hormone GM 10. IGF-I stimulates multiple cellular responses that are related to growth, including synthesis of DNA, RNA, and cellular proteins 11.
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