Accession Number:

ADB281612

Title:

Intracellular Signaling Pathways In Metastasis

Descriptive Note:

Final rept. 1 Sep 1998-31 Aug 2001

Corporate Author:

CALIFORNIA UNIV DAVIS

Personal Author(s):

Report Date:

2001-09-01

Pagination or Media Count:

11.0

Abstract:

We have preliminary evidence that both PI3K and PAK are differentially activated in the highly metastatic Met-1 tumors compared with the low metastatic Db-7 tumors. Furthermore, using micro array analysis, osteopontin OPN, a protein linked to metastatic breast cancer in humans is differentially up regulated in Met-1 tumors compared with Db-7 tumors. We have confirmed the over expression of this gene product in Met-1 tumors by immunohistochemistry and immunoblot analysis. Further analyses are necessary to establish whether there is a linkage between PI3KPAK activation and OPN expression. Preliminary data suggests that PyMT is capable of modulating the endocytosis of proteins expressed at the cell surface. Further study is required to confirm this observation.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE