Accession Number:

ADB281571

Title:

Contribution of the Receptor/Ligand Interaction Between CD44 and Osteopontin to Formation of Breast Cancer Metastases

Descriptive Note:

Annual rept. 1 Jul 2000-30 Jun 2001

Corporate Author:

NEW ENGLAND MEDICAL CENTER HOSPITAL BOSTON MA

Personal Author(s):

Report Date:

2001-07-01

Pagination or Media Count:

112.0

Abstract:

Splice variants of the homing receptor CD44 may mediate metastasis formation by various tumors through interaction with the cytokine osteopontin, which mediates cell attachment or migration. We have identified the mechanism of cell motility as a two step process involving both major osteopontin receptors. We have further characterized this process by studying signal transduction associated with ligation of each receptor. Because osteopontin structure can be extensively modified on the posttranslational and posttranscriptional levels with substantial consequences for its function we are now analyzing the osteopontin transcripts from various cancer cells for alterations.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE