Characterization of a Novel Apoptosis Regulator BI-1
Annual summary rept. 1 Jul 1999-30 Jun 2001
BURNHAM INST LA JOLLA CA
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BI-1 is an integral membrane protein that protects cells against Bax-induced cell death. It is commonly expressed in prostate cancer cell lines, making it a candidate regulator of prostate cancer cell death. I have used genetics, biochemical and cell biology approaches to understand how BI-1 regulates apoptosis. I have cloned BI-1 homologs from yeast, bacteria, Drosophila and plants, and demonstrated that they function similarly in yeast to protect Bax-induced cell death I have discovered that the yeast BI-1 homolog is important in protecting cells against heat stress. I have also determined BI-1 domains essential for its function and proper sub-cellular targeting. BI-1 KO mouse are also underway and characterization of these animals will reveal BI-1s in vivo functions.
- Anatomy and Physiology
- Medicine and Medical Research