The Role of Th1/Th2 Cytokine Balance in Gulf War-Related Illness
Final rept. 31 Jan 2000-30 Jan 2002
KING'S COLL LONDON (UNITED KINGDOM)
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The aetiology of Gulf-War GW related illnesses remains unclear. The proposal has made that multiple vaccines, given under the stress of deployment with additional effects of the T helped 2 Th2 adjuvant pertuseia could skew the immune response towards a Th2 profile. The Th2 profile, characterized by the cytokines interleukin-4 IL-4 and IL-10, has been associated with symptoms such as allergic disease, hypersensitivity and depression, symptoms characteristic of which are often reported by sick GW veterans GWVs . We studied whether self-reported illness in GWVs is associated with a Th2 shift by examining Th2 IL-4, IL-10 and Thl IL-2, interferon-7 intracellular cytokine staining in helper T lymphocytes by flow cytometry after mitogenic stimulation. We studied GWVs with and without illness, as well as a group of control servicemen with similar symptoms who were either not deployed era controls or deployed to the Bosnia conflict. We find changes in cytokine profiles in servicemen reporting multi-symptom illness. Our data suggest that deployment to the Gulf and multi-symptom illness are associated with immune activation.
- Medicine and Medical Research
- Stress Physiology