Gene Profiling of Protease Induced Genes in Breast Cancer
Final rept. 1 Sep 2000-30 Nov 2001
SCRIPPS RESEARCH INST LA JOLLA CA
Pagination or Media Count:
The thrombin receptor protease activated receptor 1, PAR-i is not detectable in non-invasive ductal carcinoma in situ, but is highly upregulated in invasive breast cancer. In breast cancer cell lines, PAR-i is expressed in more metastatic cells, conferring sensitivity to thrombin. Gene profiling of breast cancer cells stimulated with thrombin or a direct PAR-i agonist demonstrate the upregulation of genes that support cell survival and that regulate angiogenesis. Large scale gene profiling for expression tagged genes ests indicate additional downstream gene targets of thrombin signaling. These genes may prove of relevance for breast cancer progression.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research