Accession Number:

ADB275535

Title:

Imaging Angiogenesis In Vivo: 'Immunospecific' Magnetic Resonance Imaging of Breast Tumors Using Antibody-Coated Magnetic Particles

Descriptive Note:

Final rept. 1 Sep 2000-31 Aug 2001

Corporate Author:

JOHN P ROBARTS RESEARCH INST LONDON (ONTARIO)

Personal Author(s):

Report Date:

2001-09-01

Pagination or Media Count:

69.0

Abstract:

The purpose of this research is to develop a non-invasive observation of angiogenesis through the design and validation of MRI pulse sequences and novel contrast agents and to use this agent to monitor angiogenesis in vivo over time during tumor development. This is being achieved by the following 1 Optimization of MR pulse sequence technology for the relative assessment of tissue iron concentrations based on the quantitative evaluation of T2 and T2 weighted images. 2 Development of novel, highly specific iron oxide based, magnetic resonance contrast agents to be used for targeting receptors andor macrophage populations associated with tumor cells.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Nuclear Physics and Elementary Particle Physics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE