Accession Number:

ADB274630

Title:

Estrogen Metabolism and Prostate Cancer Risk

Descriptive Note:

Final rept. 1 Oct 1998-30 Mar 2001

Corporate Author:

STATE UNIV OF NEW YORK AT BUFFALO AMHERST

Personal Author(s):

• Muti, Paola

Report Date:

2001-04-01

Pagination or Media Count:

50.0

Abstract:

Experimental evidence shows that estrogens are related to prostate cancer risk - In addition recent data suggest that 16 alpha hydroxilated estrogen metabolites, biologically strong estrogens, are associated with cancer risk, while Z-hydroxyisted metabolites, with lower estrogenic activity, are weakly related to this disease. This study analyzes the association of prostate cancer with estrogen metabolism in a population-based study conducted in Erie and Niagara Counties - the Protein Study - Data in 81 prostate cancer cases and 318 control subjects showed that a higher ratio of 2 hydroxyestrone to 16 alpha hydroxyestrone uses associated with a reduced risk of prostate cancer.

Descriptors:

• *METABOLISM
• *PROSTATE GLAND
• *ESTROGENS
• *PROSTATE CANCER
• HORMONES
• RISK
• EPIDEMIOLOGY
• METABOLITES

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE