Estrogen Metabolism and Prostate Cancer Risk
Final rept. 1 Oct 1998-30 Mar 2001
STATE UNIV OF NEW YORK AT BUFFALO AMHERST
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Experimental evidence shows that estrogens are related to prostate cancer risk - In addition recent data suggest that 16 alpha hydroxilated estrogen metabolites, biologically strong estrogens, are associated with cancer risk, while Z-hydroxyisted metabolites, with lower estrogenic activity, are weakly related to this disease. This study analyzes the association of prostate cancer with estrogen metabolism in a population-based study conducted in Erie and Niagara Counties - the Protein Study - Data in 81 prostate cancer cases and 318 control subjects showed that a higher ratio of 2 hydroxyestrone to 16 alpha hydroxyestrone uses associated with a reduced risk of prostate cancer.
- Anatomy and Physiology
- Medicine and Medical Research