Accession Number:

ADB269814

Title:

A Longitudinal Study of Bone Turnover, Menopause, Aging and Ethnicity as Risk Factors for Osteoporosis

Descriptive Note:

Final rept. 25 Sep 1996-30 Apr 2001

Corporate Author:

NEW ENGLAND RESEARCH INST INC WATERTOWNMA

Personal Author(s):

• McKinlay, Sonja M.

Report Date:

2001-04-01

Pagination or Media Count:

38.0

Abstract:

This four-year study is a cost-efficient and timely longitudinal study of bone turnover markers in an ethnically diverse sample of mid-aged women as they experience the menopause transition. Building on the multi-site Study of Womens Health Across the Nation SWAN, funded by the National Institutes of Aging and Nursing Research at the National Institutes of Health, this study analyzed already collected and stored specimens of serum to measure bone formation using an immunoradiometric assay of osteocalcin and stored urine specimens to measure bone resorption using urinary N-telopeptide of type I collagen These two measures will be combined with data from SWAN on bone density spine, hip and femoral neck, ovarian aging endogenous sex hormones and menstrual bleeding, medications, medical history, social and psychological assessments, and life style factors exercise, diet, smoking, body mass to address five research aims. To date, all bone marker as says have been completed, analyses to address the research aims are presented in the attached report. Work is underway on the corresponding manuscripts.

Descriptors:

• *AGING(PHYSIOLOGY)
• *ETHNIC GROUPS
• *WOMEN
• *BONES
• *OSTEOPOROSIS
• *RISK ANALYSIS
• CASE STUDIES
• DATA ACQUISITION
• MEDICAL RESEARCH
• COLLAGEN
• HEMORRHAGE
• MENSTRUATION
• URINALYSIS
• ESTROGENS
• SEX HORMONES

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE