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Physical Activity, Body Size, Intentional Weight Loss and Breast Cancer Risk: Fellowship

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Final rept. 1 Oct 1997-30 Sep 2000

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This award supported studies examining associations between elements of energy balance and breast cancer risk. We examined the following factors in relation to breast cancer incidence 1 early life physical activity and weight interactions in postmenopausal women 2 age specific intentional weight loss 3 method of weight loss. In this interview-based study, breast cancer cases were identified from statewide registries and controls were randomly selected from population lists. For the first analysis 4614 cases, 5817 controls, reductions in postmenopausal breast cancer risk associated with regular strenuous physical activity GE 1day were greatest for women in the 4th quartile of body mass index at age 18 OR--O.45, 95 CI 0.26-0.79. Also, compared to women with no activity and little adult weight gain, frequent physical activity as associated with a significant risk reduction in women who lost weight OR0.19, CI 0.05-0.70. For the next two analyses 2156 cases, 2833 controls extensive weight loss history was ascertained. After adjustment, substantial intentional weight loss of lbs in the teens was associated with significant breast cancer risk reduction OR--0.43, CI 0.19-0.99. Of the 13 weight loss methods reported, the most common method was low calorie diets 36. None of the specific methods were independently associated with breast cancer risk.

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  • Anatomy and Physiology
  • Medicine and Medical Research

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