Cellular and Molecular Roles of the Akt Protein Kinase in Breast Carcinomas
Annual rept. 4 May 1999-3 May 2000
MICHIGAN UNIV ANN ARBOR
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Akt is a serinethreonine kinase that has been implicated in the initiation andor progression of breast cancers. In order to gain an understanding of how Akt promotes malignant transformation, we identified proteins that are regulated by phosphorylation by Akt, including a POU domain family transcription factor and the B-Raf serinethreonine kinase. Whereas Akt may upregulate gene expression through phosphorylation of the POU domain transcription factor, Akt negatively regulates B-Raf activity in vitro and in vivo by phosphorylating two residues in the amino-terminal regulatory domain of B-raf.
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