Magnetic Resonance Arterial Spin Tagging for Non-Invasive Pharmacokinetic Analysis of Breast Cancer
Annual rept. 30 Sep 1999-29 Sep 2000
CALIFORNIA UNIV DAVIS
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This research project concerns the development of MRI arterial spin tagging to non-invasively measure breast tissue perfusion. The specific aims are to 1 refine arterial spin tagging pulse sequences 2 develop automated data analysis software and 3 compare the technique to first-pass contrast-enhanced MRI and biopsy. The scope of effort has been mainly limited to technical developments. During the first two years, the spin-tagging pulse sequences were developed for the GE l.5T Horizon LX CVI MRI system at UC Davis. New image processing software, and software for statistical analysis of spin tagging and contrast enhanced dynamic scans, were written for use in the clinical setting. Year three the project included a clinical comparison with first-pass, contrast-enhanced MRI in 60 patients with unbiopsied breast masses, for aim 3. However, these studies were not done, due to the inability to recruit patients. The grant funds were not spent. Official approval has been granted for a one-year no-cost extension. A new co-investigator and patient referral pattern should improve patient recruitment in this upcoming fourth year of the project.
- Medicine and Medical Research