Accession Number:

ADB265247

Title:

Measurements of Breast Tissue Optical Properties

Descriptive Note:

Annual summary rept. 30 Sep 1999-29 Sep 2000

Corporate Author:

BECKMAN LASER INST AND MEDICAL CLINIC IRVINE CA

Personal Author(s):

Report Date:

2000-10-01

Pagination or Media Count:

131.0

Abstract:

Near-infrared NIR optical spectroscopy demonstrates unique possibilities for non-invasively monitoring tissue physiology. A bedside-capable instrument, using low levels of non-ionizing NIR light delivered by a hand-held probe, measures both absorption and scattering properties of tissues. A diffusive model for photons traveling through large tissue volumes quantifies oxygenated and deoxygenated hemoglobin, water, and lipid by their absorption signatures. Cellular density, fat, and collagen content are evaluated from the measured light- scattering spectra. This quantitative functional information cannot be obtained with other non-invasive radiological techniques. The prototype instrument revealed physiological changes in breast consistent with age-dependent histological alterations in 28 healthy female volunteers. A preliminary in vivo measurement of the therapeutic efficacy of two chemotherapy agents on a tumor in a human subject is also presented.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Optics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE