Identification of Telomerase Components and Telomerase Regulating Factors in Yeast
Final rept. 1 Jul 1997-30 Jun 2000
BAYLOR COLL OF MEDICINE HOUSTON TX
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Telomeres, specialized structures at the ends of chromosomes, help maintain the stability of the genome and are essential for continued cell proliferation. The purpose of this research has been to understand the processes involved in maintaining the length and integrity of chromosome ends using the yeast S. cerevisiae as a model system. This work has helped to define three genetic pathways that are critical for telomere function and replication one defined by the Ku complex, a second comprises telomerase and MREll, RAD5O, and XRS2, and the third identified by CDCl3 and STNl. Although chromosome ends must be functionally distinct from DNA double strand breaks, genes involved in DNA double-strand break repair were found to play critical roles in two of these genetic pathways for maintaining telomeres.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research