Accession Number:

ADB264450

Title:

Characterization of a Novel Apoptosis Regulator BI-1

Descriptive Note:

Annual rept. 1 Jul 1999-30 Jun 2000

Corporate Author:

BURNHAM INST LA JOLLA CA

Personal Author(s):

Report Date:

2000-07-01

Pagination or Media Count:

11.0

Abstract:

BI-l is an important cell death regulator that protects cells against Bax-induced cell death. It is expressed in all four prostate cancer lines and overexpresed in two of them, making it an important regulator in prostate cancer progression. I have used genetics, biochemical and cell biology approaches to understand how BI-l regulate apoptosis and possibly prostate cancer. I have demonstrated the in vivo function of BI-l homolog in yeast I have discovered that BI-l homologs from different species, including plant, fly, yeast and E. coli can function similarly in yeast to protect Bax-induced cell death. I have also mapped important BI-l domains essential for its function. These provide the basis for understanding the mechanism through which BI-l regulates apoptosis.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE