Accession Number:
ADB264450
Title:
Characterization of a Novel Apoptosis Regulator BI-1
Descriptive Note:
Annual rept. 1 Jul 1999-30 Jun 2000
Corporate Author:
BURNHAM INST LA JOLLA CA
Personal Author(s):
Report Date:
2000-07-01
Pagination or Media Count:
11.0
Abstract:
BI-l is an important cell death regulator that protects cells against Bax-induced cell death. It is expressed in all four prostate cancer lines and overexpresed in two of them, making it an important regulator in prostate cancer progression. I have used genetics, biochemical and cell biology approaches to understand how BI-l regulate apoptosis and possibly prostate cancer. I have demonstrated the in vivo function of BI-l homolog in yeast I have discovered that BI-l homologs from different species, including plant, fly, yeast and E. coli can function similarly in yeast to protect Bax-induced cell death. I have also mapped important BI-l domains essential for its function. These provide the basis for understanding the mechanism through which BI-l regulates apoptosis.
Descriptors:
Subject Categories:
- Anatomy and Physiology
- Medicine and Medical Research