Characterization of a Novel Apoptosis Regulator BI-1
Annual rept. 1 Jul 1999-30 Jun 2000
BURNHAM INST LA JOLLA CA
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BI-l is an important cell death regulator that protects cells against Bax-induced cell death. It is expressed in all four prostate cancer lines and overexpresed in two of them, making it an important regulator in prostate cancer progression. I have used genetics, biochemical and cell biology approaches to understand how BI-l regulate apoptosis and possibly prostate cancer. I have demonstrated the in vivo function of BI-l homolog in yeast I have discovered that BI-l homologs from different species, including plant, fly, yeast and E. coli can function similarly in yeast to protect Bax-induced cell death. I have also mapped important BI-l domains essential for its function. These provide the basis for understanding the mechanism through which BI-l regulates apoptosis.
- Anatomy and Physiology
- Medicine and Medical Research