Polycyclic Aromatic Hydrocarbon (PAH) -DNA Adducts and Breast Cancer
Annual summary 1 Oct 1998-30 Sep 1999
COLUMBIA UNIV NEW YORK
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While immunofluoresence has begun on the 800 samples proposed, the start date for this was pushed back from the original date proposed to 699 due to equipment difficulties and the purchase of a new camera and software to increase sensitivity of the assay. In the meantime,the principal investigator, Sharon Hayes began and finished a project not originally proposed in the funded grant proposal. The 800 breast cancer cases and controls have been genotyped for a polymorphism in the DNA repair gene XPD. Cancer Research 58, 604-608, Feb 15,1998 The samples are from the parent study, the Long Island Breast Cancer Research Project, and we are not permitted to publish this data until the primary hypotheses from this study are published. I am blinded to the status of the samples until I finish the immunfluoresence then both papers should be published. The immunofluorescence should be finished within 6 months and analysis of both the 800 samples for both projects originally funded and the XPD project should begin at that time. We have received 60 tissue samples for analysis.
- Medicine and Medical Research