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Physical Activity, Body Size, Intentional Weight Loss and Breast Cancer Risk: Fellowship

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Annual rept. 1 Oct 1998-30 Sep 1999

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This training award supports studies to describe associations between breast cancer risk and elements of energy balance. As part of an ongoing, population-based case-control study of breast cancer, associations between intentional weight loss at multiple time periods and risk of breast cancer were examined. Breast cancer patients were identified from statewide tumor registries in Massachusetts, New Hampshire, and Wisconsin from 1996-1998. Similarly aged control women were randomly selected from population lists. Information on intentional weight loss and breast cancer risk factors was obtained through telephone interviews. Data were collected for 2156 cases and 2833 controls. Logistic regression was used to compute odds ratios OR and 95 confidence intervals CI. After adjustment for age, body size, number of weight loss episodes and other risk factors, reduced odds of breast cancer were observed for intentional weight loss during the teens 60 pounds ORO.43, CI-0.l9-0.99 and forties 40-69 pounds ORO.60, CIO.36-l.00. Cumulative intentional weight loss 120 pounds was associated with a 43 reduction in risk ORO.57, CIO.37-O.89. Associations with cumulative weight loss were more pronounced in women who gained substantial amounts of weight. These results suggest that large amounts of intentional weight loss, independent of attained weight, may be associated with a reduced risk of breast cancer.

Subject Categories:

  • Medicine and Medical Research
  • Food, Food Service and Nutrition
  • Stress Physiology

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