Functional Interactions Between c-Src and HER1 Potentiate Neoplastic Transformation: Implications for the Etiology of Human Breast Cancer
Final rept. 1 Jul 1997-30 Jun 2000
VIRGINIA UNIV CHARLOTTESVILLE
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In cells where the EGF receptor and pp60c-Src are overexpressed, such as a fibroblast model system or in certain human breast cancer cell lines, these two tyrosine kinases interact physically and functionally to promote tumorigenesis. When in association with c-Src, the EGFR becomes phosphorylated within the kinase domain on Tyr 845. Kinase activity of c-Src is required for this phosphorylation to occur, indicating that Tyr 845 is likely a direct target for the c-Src kinase. Tyr 845 phosphorylation occurs in response to a variety of 0-protein coupled and cytokine receptor coupled signaling pathways and c-Src kinase activity is required for this phosphorylation to occur.
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