Accession Number:

ADB263448

Title:

The Sentinel Lymph Node as a Disease Prognosticator in Node Negative Breast Cancer

Descriptive Note:

Final rept. 1 Oct 1997-31 May 2000

Corporate Author:

JOHNS HOPKINS UNIV BALTIMORE MD SCHOOLOF MEDICINE

Personal Author(s):

Report Date:

2000-06-01

Pagination or Media Count:

44.0

Abstract:

The purpose of this study is to use sentinel node technology to better predict prognosis for node-negative breast cancer patients. Patients with a new diagnosis of unilateral, unifocal breast cancer and a clinically negative axilla were offered enrollment in this protocol. Sentinel nodes were localized and resected along with a standard staging axillary dissection. The sentinel nodes were processed in standard fashion and were then retained for specialized studies including microsectioning and telomerase studies. Short term goals are to determine the proportion of patients considered to be node-negative who harbor micrometastasis or telomerase in the sentinel node and to determine the association of nuclear grade in Ki67 with the finding of micrometastasis in the sentinel node. Long term goals include evaluation of the association of sentinel node micrometastasis and telomerase with disease free survival and overall survival. In the time interval covered by this report, a total of 150 patients ranging in age from 35-87. A enrolled patients have been female. Short term technical outcomes and some pathologic outcomes are presented in this report. Long term outcomes are pending as required by protocol.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Escape, Rescue and Survival

Distribution Statement:

APPROVED FOR PUBLIC RELEASE