Roles of Breast Cancer Genes in DNA Homologous Recombination and Cellular Sensitivity to Radiation and Anticancer Drugs
Annual rept. 1 Sep 1999-31 Aug 2000
ILLINOIS UNIV AT CHICAGO
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The major objectives of this IDEA award are 1 to identify new proteins that may interact with BRCA2 in order to elucidate novel cellular function of BRCA2, and 2 to confirm that BRCA2 plays roles in DNA homologous recombination and cellular sensitivity to DNA damage. Progress has been made in the last year to achieve these objectives. We have identified 2 new protein interaction partners of BRCA2. One of the new partners is a novel protein, BCCIP alpha. BCCIP alpha gene is located on chromosome 10q26.1, a region susceptible for many human cancers. Another partner is a known protein that involved in cytoskeleton structure. The identification of these new BRCA2 interaction partners could reveal more functional roles of BRCA2 in mammary tumorigenesis. We are in the process of establishing BRCA2 dominant negative expression system to study the role of BRCA2 in homologous recombination and cellular sensitivity to DNA damage.
- Medicine and Medical Research