Role of Cyclin D1 and cdk Inhibitors in Breast Cancer Pathogenesis
Annual summary rept. 30 Sep 1998-29 Sep 1999
PENNSYLVANIA UNIV PHILADELPHIA
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Extensive molecular, biochemical, cell biological, and cytogenetic studies of breast cancer cell lines and breast cancer biopsies have indicated that overexpression of cyclin Dl plays an important role in breast tumor oncogenesis. The connections between cyclin D and tumorigenesis are strengthened by compelling evidence that D-type cyclins are fundamental to cell cycle regulation of the tumor suppressor protein, Rb. However, overexpression of cyclin Dl fails to induce anchorage-independent cell proliferation and also fails to reproducibly stimulate growth in epithelial cell lines. Furthermore, analysis of breast cancer biopsies indicate that cyclin Dl is overexpressed to the same degree in both the early and late stages of breast cancer.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research