Racial Differences in Breast Cancer Clinical Characteristics, Biology, and Treatment
Final rept. 1 Jul 1994-30 Jun 1999
MISSOURI UNIV-KANSAS CITY
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African-American and caucasian women with newly diagnosed breast cancer were enrolled in the study. Upon enrollment, demographic data, tumor characteristics, and tumor staging data were obtained. Tumor samples were evaluated for estrogen and progesterone receptor levels, DNA ploidy, S-phase fraction, HER-2lneu expression, p53 protein accumulation, cathepsin D levels, and glutathione levels. Treatment choices, treatment received, relapse site and date, and date and cause of death were recorded in follow-up. There were 181 women enrolled in the study. No racial differences in clinical presentation, tumor stage, tumor biologic characteristics, or treatment have been identified. In addition, there has been no difference in time to treatment failure or overall survival. We conclude that economically similar black and white women with breast cancer are likely to have similar clinical manifestations and outcomes.
- Medicine and Medical Research