Total Synthesis of Eleutherobin and Analogs and Study of Anti-Cancer Mechanism
Annual summary rept. 1 Apr 1999-30 Apr 2000
SLOAN-KETTERING INST FOR CANCER RESEARCH NEW YORK
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Eleutherobin is a marine natural product discovered in 1994. It serves as one of the most potent anti-cancer agents mimicking Taxol. The proposed research is focused on improving the total synthesis of eleutherobin, and based on that developing eleutherobin analogs for biological studies. A modified eleutherobin synthesis is being studied. Compared to the initial Synthesis, the new synthesis is designed to improve the stereoselectivity of key steps and shorten the sequence.
- Medicine and Medical Research
- Physical Chemistry