Accession Number:

ADB261339

Title:

Total Synthesis of Eleutherobin and Analogs and Study of Anti-Cancer Mechanism

Descriptive Note:

Annual summary rept. 1 Apr 1999-30 Apr 2000

Corporate Author:

SLOAN-KETTERING INST FOR CANCER RESEARCH NEW YORK

Personal Author(s):

Report Date:

2000-05-01

Pagination or Media Count:

14.0

Abstract:

Eleutherobin is a marine natural product discovered in 1994. It serves as one of the most potent anti-cancer agents mimicking Taxol. The proposed research is focused on improving the total synthesis of eleutherobin, and based on that developing eleutherobin analogs for biological studies. A modified eleutherobin synthesis is being studied. Compared to the initial Synthesis, the new synthesis is designed to improve the stereoselectivity of key steps and shorten the sequence.

Subject Categories:

  • Biology
  • Medicine and Medical Research
  • Physical Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE