Identification of Checkpoint Genes Involved in the kar3 Cell Cycle Arrest
Annual rept. 15 Aug 1999-14 Aug 2000
TUFTS UNIV BOSTON MA
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KAR3 encodes a kinesin-like motor protein that has a wide variety of roles in the budding yeast Saccharomyces cerevisiae. Genetic bypass studies and a mutant hunt are being done to discern the nature of the kar3A meiotic arrest and to find genes involved in the checkpoint function that mediates the arrest. Checkpoints are important regulatory mechanisms used by cells to prevent aberrant cell cycle divisions such as those observed in cancerous cells. In addition Kar3p functions are thought to be determined by interaction with a number of kinesin associated proteins KAPs including Cik1p and Vik1p. We are exploring the roles of these KAPs in meiosis.
- Anatomy and Physiology
- Medicine and Medical Research