Screening for Ataxia-Telangiectasia Mutations in a Population-Based Sample of Women with Early-Onset Breast Cancer
Final rept. 19 Aug 1996-18 Aug 1999
VIRGINIA MASON RESEARCH CENTER SEATTLE WA
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We are assessing whether a mutated allele of the Ataxia-telangiectasia gene, ATM, is a genetic risk factor for breast cancer, by screening for ATM mutations in patients with early- onset breast cancer. These patients were derived from a large population-based, case-control study of primary breast cancer in Western Washington. We are screening genomic DNAs by SSCP single strand conformation polymorphism analysis of the 62 coding exons amplified by multiplex PCR. In 142 breast cancer cases with early-onset or family history, we have found no truncation or deletion mutations in the ATM gene. family history of breast cancer.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research