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Magnetic Resonance Spectroscopy: An Objective Modality to Identify the Pathology of Breast Neoplasms

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Annual rept. 29 Apr 1998-28 Apr 1999

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Proton MRS on FNA distinguishes benign breast lesions from invasive cancer with a sensitivity and specificity of 95 and 96, respectively. Carcinoma in situ specimens are ranked by proton MRS as benign or malignant. This ranking is not explained by standard histopathological criteria, suggesting MRS is reporting on differences which are not morphologically manifest. FNA MR spectra with signal to noise ratios SNR25 are required to ensure a correlation of MRS and histopathological data with a high sensitivity and specificity when visual inspection methods alone are employed. Computerised Consensus Diagnosis CCD, however, distinguishes benign and malignant lesions with high sensitivity and specificity for FNA spectra including those with SNR25. CCD is also able to predict the presence or absence of vascular invasion and lymph node involvement for patients with invasive breast lesions. Two dimensional MRS fails to discriminate between breast tissues due to large lipid contribution to the spectra or breast FNAs due to inadequate signal to noise. Proton MRS on FNA and Magic Angle Spinning MAS MRS detects metastatic disease in axillary lymph nodes from breast cancer patients.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Electricity and Magnetism

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